And the plague of firearm deaths continues…from Katelyn Jetelina’s Your Local Epidemiologist:

“Almost immediately, social media seized on the tragedy to argue that Australia’s strict gun laws don’t work. I’ll stop that right there. This isn’t a debate because the data are crystal clear:

1. 1. Mass shootings are extremely rare in Australia. Since the Port Arthur massacre in 1996, strict firearm regulations (a buyback program and tight licensing) have kept mass shootings to zero or one per year on average in Australia. By contrast, the U.S. experiences roughly 400–650 mass shootings annually, with more than 46,000 deaths from gun violence each year. As the graph below shows, it’s not even close.
      
   2. A tragedy does not disprove the effectiveness of these laws. Data show that strict regulations reduce deaths. Beyond Australia, places like the U.K., Japan, and Canada have similarly strict gun laws and extremely low rates of mass shootings. We can also see variability within the United States. States with the most lax gun laws have the highest rates of gun violence.
   3. Firearm deaths are the leading cause of death for children in the U.S., whereas in Australia, child deaths from firearms are extremely rare, with suicide and road accidents being the top causes.”

Maxwell Kennedy writes evocatively about his father Bobby Kennedy’s legacy in the Boston Globe.  I was 14 and remember being absolutely devastated when RFK was assassinated.  Reading this essay reminds me of how incredibly far the quality of our leadership has plummeted.

From Heather Cox Richardson’s Letters from an American:

“Today, former U.S. district judge Mark L. Wolf, who was appointed to the U.S. District Court for the District of Massachusetts by President Ronald Reagan, explained that he resigned on Friday because he wanted the freedom to do “everything in my power to combat today’s existential threat to democracy and the rule of law.” Wolf called out Trump’s use of the Department of Justice to hurt his political opponents, his firing of inspectors general, the administration’s pay-to-play policies in which wealthy donors get government favors, the corruption of cryptocurrency, unconstitutional executive orders, and the threats against judges as Trump attacks the rule of law.”

Kudos to Judge Wolf.  His Atlantic essay Why I am Resigning is here.

From Bernard C, Duchemin T, Marty L, et al. First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies. JAMA Netw Open. 2025;8(10):e2538039. doi:10.1001/jamanetworkopen.2025.38039:

“Question  Are messenger RNA (mRNA)–based COVID-19 vaccines teratogenic ?

Findings  In this nationwide cohort study of 527 564 live-born infants, 130 338 (24.7%) were exposed to an mRNA-based COVID-19 vaccine during the first trimester of pregnancy. There was no association with an increased risk for 75 different major congenital malformations, whether examined overall, grouped by organ systems, or individually.”

Res ipsa loquitur.

Having in the past administered a lot of rabies PEP with RIG and the vaccine, I thought this new rabies PEP alternative was pretty cool; from a UMass Chan press release:

A new post-licensure clinical study published in The Lancet further demonstrates that Rabishield, a monoclonal antibody therapy developed by UMass Chan Medical School in partnership with the Serum Institute of India, offers a safe and effective alternative to older rabies treatments. In India, rabies kills an estimated 20,000 people every year—two people every hour. 

In the new study, more than 4,000 patients in India who had high-risk animal bites received either Rabishield plus a rabies vaccine or the traditional equine rabies immunoglobulin plus vaccine. Both groups developed strong immune responses, but Rabishield was better tolerated, with fewer serious side effects. Importantly, no participants developed rabies during a year of follow-up.