Medscape Newsfeed:
- FDA Approves Two Oral JAK Inhibitors for Atopic Dermatitis
Upadacitinib and abrocitinib are the first oral JAK inhibitors approved for treating atopic dermatitis. Medscape Medical News
- FDA Updates Status of iPLEDGE Access Problems
The Isotretinoin Products Manufacturers Group has "created a new tool within the system to help resolve account access for some user groups without using the call center." Medscape Medical News
- Ivermectin Scripts for COVID Cost Insurers Nearly $130M Annually
Most prescriptions are being written for COVID-19, although there's no evidence that it's effective against the virus. Medscape Medical News
- Docs Pen Open Letter to Support Fauci From Partisan 'Attacks'
Fed up with personal attacks directed at the nation's top infectious disease expert, leading scientists and physicians sign an open letter of support and gratitude for Fauci's 'sagacious counsel.' Medscape Medical News
- Antidepressants: Is Less More?
A new review suggests antidepressants' efficacy is questionable, leading researchers to recommend that when these agents are prescribed, it should be for shorter periods. Medscape Medical News
NIH Newsfeed:
- NIH researchers develop first stem cell model of albinism to study related eye conditions
Use of patient-derived stem cells will enable high-throughput drug screening for potential therapeutics.
- COVID-19 vaccination associated with a small, temporary increase in menstrual cycle length, suggests NIH-funded study
The authors noted that menstrual cycles typically vary a small amount from month to month.
- Sleep-disordered breathing in early pregnancy linked to insulin resistance
NIH-funded findings suggest screening for sleep disordered breathing may help in reducing gestational diabetes risk.
EM Journal Watch Newsfeed:
- Nonresponsiveness to Antibiotics in Acute Uncomplicated Appendicitis
Appendiceal diameter of ≥15 mm or fever >38°C were associated with higher likelihood of early antibiotic failure and need for surgery.
- Calcium in Out-of-Hospital Cardiac Arrest: No Benefit
Intravenous or intraosseous calcium administration did not improve outcomes and might be harmful.
- First-Pass Intubation Is Similarly Successful with Stylet or Bougie
Patients were intubated successfully on the first attempt 80% of the time, regardless of approach.
- Many Patients with Alcohol Withdrawal in Intensive Care Don't Receive Thiamine
The practice is even less common in patients with alcohol use disorder admitted to ICUs for other critical illnesses.
- New Surviving Sepsis Guidelines
In this update, recommendations include using balanced crystalloid for resuscitation and steroids for persistent shock.