Medscape Newsfeed:
- IVIG Prophylaxis in Myeloma Cuts Infections, Ups Survival
IVIG prophylaxis led to improvements in infection-free survival as well as progression free and overall survival in patients with multiple myeloma. Medscape Medical News
- Rilzabrutinib Shines in Phase 3 Trial of Tough-to-Treat ITP
The oral BTK inhibitor rilzabrutinib led to rapid and durable platelet responses, reduced bleeding, and improved fatigue in patients with previously treated immune thrombocytopenia. Medscape Medical News
- 24-Hour Urine Testing in Multiple Myeloma: Time to Stop?
Including 24-hour urine testing in multiple myeloma response assessments is largely unnecessary, a new phase 3 trial suggests. Medscape Medical News
- LBCL: Bispecific Antibodies Fare Less Well in Real-World Analysis
In the real world, treating relapsed/refractory large B-cell lymphoma with epcoritamab and glofitamab leads to poorer outcomes than in clinical trials. Medscape Medical News
- Common Herbicide a Player in Neurodegeneration?
Exposure to glyphosate, the most widely used herbicide, exacerbates neuroinflammation and AD-like pathology in mice, with effect lasting even after a significant pause from exposure. Medscape Medical News
NIH Newsfeed:
- Single mutation in H5N1 influenza surface protein could enable easier human infection
NIH-funded study finds risk of human infection continues to remain low.
- In five cancer types, prevention and screening have been major contributors to saving lives
NIH modeling study looked at the individual and combined impacts of cancer prevention, screening, and treatment.
- Abnormal prenatal blood test results could indicate hidden maternal cancers
NIH study finds some abnormal results due to colorectal, breast, lung and pancreatic cancers.
- Newer epilepsy medications used during pregnancy do not affect neurological development in children
NIH-funded study provides clarity on safety of two common antiseizure drugs lamotrigine and levetiracetam.
EM Journal Watch Newsfeed:
- Should Urea Be Used for Managing SIADH?
A recent meta-analysis suggests that it is safe and effective for syndrome of inappropriate antidiuretic hormone secretion.
- Optimal Hemoglobin Threshold for Patients with Acute Brain Injury
In a randomized trial, critically ill patients with acute brain injury who were transfused to a higher hemoglobin goal had better neurological outcomes.
- What Is the Optimal Hemoglobin Transfusion Threshold in Patients with Myocardial Infarction?
It's probably 9 g/dL in patients with MI and anemia.
- What's the Best Intravenous Fluid for Sickle Cell Vaso-Occlusive Crisis?
Lactated Ringer's solution, compared with normal saline, was associated with small but significant improvements in outcomes.
- Preventing Hypoxemia with Noninvasive Ventilation During Emergency Intubation
In a randomized trial, preoxygenation with NIV significantly and safely lowered the incidence of hypoxemia in critically ill adults.