• Tomas Pueyo, writing in his Uncharted Territories  substack blog takes a good hard look at the Cochrane Library’s meta analysis of the “Physical interventions to interrupt or reduce the spread of respiratory viruses” by Dooley et al. used by some (e.g. Bret Stephens in the NYT) to erroneously conclude that mask mandates are ineffective.  In reality, no such conclusion can be drawn from the Dooley review — the authors themselves state “The high risk of bias in the trials, variation in outcome measurement, and relatively low adherence with the interventions during the studies hampers drawing firm conclusions.” and “We are uncertain whether wearing masks or N95/P2 respirators helps to slow the spread of respiratory viruses based on the studies we assessed.”  Pueyo does a good job of analyzing why this review does not provide any substantive evidence that mask mandates are ineffective.

• Jeremy Faust writes in his Substack Inside Medicine blog about how more and more Americans are choosing to die at home; it’s worth a read. Some numbers from his post:

• Jeremy Peters and Katie Robertson write in the NY Times about some of the noisome evidence produced in the Dominion defamation case. For me, the most heinous indictment in their story comes in this quote from Rupert Murdoch:

“On one occasion, as Mr. Murdoch watched Mr. Giuliani and Ms. Powell on television, he told Suzanne Scott, chief executive of Fox News Media, “Terrible stuff damaging everybody, I fear.””

Murdoch knew the damage he was doing to people and to this country and yet persisted, all in the interest of $$. Read the story, it says it all about the profit driven business plan of his media empire, one built on lies and fear-stoking.

• Dr F. Perry Wilson of the Yale School of Medicine writes on Medscape about this interesting article from Plos One: “U.S. state policy contexts and mortality of working-age adults” by Montez, Mohri, Monnat, et al.  Dr. Wilson thinks that average education level may be the primary factor for the life expectancy discrepancy between states rather than state policies, but the authors in their abstract suggest that state policies may have a large impact:

“Simulations indicate that changing all policy domains in all states to a fully liberal orientation might have saved 171,030 lives in 2019, while changing them to a fully conservative orientation might have cost 217,635 lives.”

and in their discussion:

“On average, Americans die younger than their peers in most other high-income countries. In a 2013 U.S. survey, 85% of adult respondents indicated that their ideal life span was 79 years or older, yet U.S. life tables predicted that only 60% of people born that year could expect to survive to age 79 [40, 41]. Our findings, which examine working-age deaths among adults ages 25–64 years, suggest state policies–specifically, their left/right lean–may be a contributing factor and provide new insights into potential strategies to reduce working-age mortality.”

• An excellent podcast by Ezra Klein, interviewing Gary Marcus’ “Skeptical Take on the A.I. Revolution”; definitely worth a listen.

• Mihir Desai at HBS and HLS opines — correctly in my mind — about the illusory promises of the crypto kingdom in his opinion piece in the NYT.

• Yet another example of how our American health care payment systems are completely bonkers:

Goodbill researched hospital charges for a liter of saline; available online for about $10, some hospitals were charging many thousands of dollars (in one case $26,667.03!!!) for a bag of N.S.  Goodbill used the machine readable lists of hospital prices mandated by the Hospital Price Transparency Rule to grab the data.

What a mess.

• David Marchese interviews Yejin Choi in the NYT; what I found to be an excellent discussion of where the science stands right now ensues.

• John Gruber’s Daring Fireball has a good post on Twitter and Musk’s recent machinations; recommended. One excerpt:

“But it gets better. Last night Twitter began classifying all links to all popular Mastodon servers as “malware”. That includes links to one’s own Mastodon account that a Twitter user might put in their account profile”

• I’ll be sad to see the wonderful Tony Fauci step down from his role at the NIAID.  He’s a wonderful man, and a true icon — especially for physicians like me who practiced through the beginnings of the AIDs epidemic and the subsequent discoveries of effective treatments. We’ll miss his resolute leadership and integrity.  He has a parting message “to the next generation of scientists and health workers” published in the NY Times.